Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) waa carotenoid, oo loo kala saaro lutein, oo laga helo noocyo badan oo noolaha yaryar iyo xayawaanka badda, waxaana asal ahaan ka soocay aargoosatada Kuhn iyo Sorensen. Waa midab dufan leh oo u muuqda casaan oranji ilaa casaan qoto dheer mana laha firfircooni fiitamiin A ah oo ku jirta jirka aadanaha.
Ilaha dabiiciga ah ee astaxanthin waxaa ka mid ah algae, khamiir, kalluun salmon, kalluun kalluun, krill iyo crayfish. Astaxanthin-ka ganacsiga waxaa inta badan laga helaa khamiirka Fife, algae cas iyo isku-darka kiimikada. Mid ka mid ah ilaha ugu wanaagsan ee astaxanthin-ka dabiiciga ah waa chlorella cas oo roob lagu shubo, oo leh astaxanthin oo qiyaastii ah 3.8% (miisaanka qalalan), kalluunka salmon-ka duurjoogta ahna sidoo kale waa ilo wanaagsan oo astaxanthin ah. Wax soo saarka synthetic-ga ayaa weli ah isha ugu weyn ee astaxanthin sababtoo ah qiimaha sare ee beerista baaxadda weyn ee Rhodococcus rainieri. Dhaqdhaqaaqa bayoolojiga ee astaxanthin-ka si farsamaysan loo soo saaray waa 50% oo keliya kan astaxanthin-ka dabiiciga ah.
Astaxanthin wuxuu u jiraa sida stereoisomers, isomers joomatari ah, qaabab xor ah oo esterified ah, iyadoo stereoisomers (3S,3'S) iyo (3R,3'R) ay yihiin kuwa ugu badan ee dabiiciga ah. Rhodococcus rainieri wuxuu soo saaraa isomer-ka (3S,3'S) halka khamiirka Fife uu soo saaro isomer-ka (3R,3'R)-ka.
Astaxanthin, kulaylka waqtiga
Astaxanthin waa maaddada ugu muhiimsan ee cuntooyinka shaqeeya ee Japan. Tirakoobka FTA ee ku saabsan ku dhawaaqyada cuntada shaqeynaya ee Japan sannadkii 2022 ayaa lagu ogaaday in astaxanthin uu ka mid ahaa 10-ka maaddooyin ee ugu sarreeya marka loo eego inta jeer ee la isticmaalo, waxaana inta badan loo isticmaali jiray dhinacyada caafimaadka ee daryeelka maqaarka, daryeelka indhaha, yareynta daalka, iyo horumarinta shaqada garashada.
Abaalmarinta Maaddooyinka Nafaqada Aasiya ee 2022 iyo 2023,Caafimaadka Justgood Maaddada astaxanthin ee dabiiciga ah ayaa loo aqoonsaday inay tahay maaddada ugu fiican sanadka laba sano oo isku xigta, maaddada ugu fiican ee ku jirta wadada shaqada garashada sanadka 2022, iyo maaddada ugu fiican ee wadada quruxda afka sanadka 2023. Intaa waxaa dheer, maaddada waxaa lagu soo daray liiska abaalmarinta Aasiyaanka Waxyaabaha ku jira Nafaqada - Agingka Caafimaadka leh sanadka 2024.
Sannadihii ugu dambeeyay, cilmi-baarista tacliimeed ee ku saabsan astaxanthin ayaa sidoo kale bilaabatay inay kululaato. Sida laga soo xigtay xogta PubMed, horraantii 1948, waxaa jiray daraasado ku saabsan astaxanthin, laakiin feejignaantu way hoosaysay, laga bilaabo 2011, akadeemiyadu waxay bilaabeen inay diiradda saaraan astaxanthin, iyadoo la daabacay in ka badan 100 daabacaad sannadkii, iyo in ka badan 200 sannadkii 2017, in ka badan 300 sannadkii 2020, iyo in ka badan 400 sannadkii 2021.
Isha sawirka: PubMed
Marka laga hadlayo suuqa, sida laga soo xigtay aragtida suuqa ee mustaqbalka, cabbirka suuqa astaxanthin ee adduunka waxaa lagu qiyaasay inuu yahay USD 273.2 milyan sanadka 2024 waxaana la saadaalinayaa inuu gaaro USD 665.0 milyan marka la gaaro 2034, iyadoo CAGR uu yahay 9.3% inta lagu jiro xilliga saadaasha (2024-2034).
Awoodda antioxidant-ka oo sareysa
Qaab-dhismeedka gaarka ah ee Astaxanthin wuxuu siinayaa awood antioxidant oo heer sare ah. Astaxanthin wuxuu ka kooban yahay isku xidhnaan labanlaab ah, kooxo hydroxyl iyo ketone ah, waana lipophilic iyo hydrophilic labadaba. Xidhmada labanlaab ee isku xidhan ee ku taal bartamaha isku-dhafka ayaa bixisa elektaroono waxayna la falgashaa xagjirro xor ah si ay ugu beddelaan alaabooyin aad u deggan oo ay u joojiyaan falcelinta silsiladda xagjirka xorta ah ee noolaha kala duwan. Hawlgalkeeda bayoolojiga ayaa ka sarreeya kuwa antioxidants-ka kale sababtoo ah awooddeeda ay ugu xidhmi karto xuubka unugyada gudaha dibadda.
Meesha ay astaxanthin iyo antioxidants-ka kale ku yaalaan xuubka unugyada
Astaxanthin wuxuu sameeyaa firfircooni antioxidant oo muhiim ah ma aha oo kaliya isagoo si toos ah u baadhaya xagjirrada xorta ah, laakiin sidoo kale wuxuu ku shaqeeyaa nidaamka difaaca antioxidant-ka unugyada isagoo nidaaminaya marinka factor erythroid 2-related factor (Nrf2). Astaxanthin wuxuu joojiyaa sameynta ROS wuxuuna nidaamiyaa muujinta enzymes-ka jawaaba walbahaarka oksaydhka, sida heme oxygenase-1 (HO-1), kaas oo ah calaamad muujinaysa walbahaarka oksaydhka. HO-1 waxaa nidaamiya noocyo kala duwan oo arrimo qoraal ah oo xasaasi u ah walbahaarka, oo ay ku jiraan Nrf2, kaas oo ku xidha walxaha jawaaba antioxidant-ka ee gobolka dhiirrigeliyaha ee enzymes-ka dheef-shiid kiimikaadka ee sunta.
Noocyada buuxa ee faa'iidooyinka iyo codsiyada astaxanthin
1) Hagaajinta shaqada garashada
Daraasado badan ayaa xaqiijiyay in astaxanthin uu dib u dhigi karo ama uu hagaajin karo cilladaha garashada ee la xiriira gabowga caadiga ah ama uu yareyn karo cudurada kala duwan ee neerfaha. Astaxanthin wuxuu ka gudbi karaa caqabadda dhiigga-maskaxda, daraasaduhuna waxay muujiyeen in astaxanthin-ka cuntada uu ku ururo hippocampus iyo cerebral cortex ee maskaxda jiirka ka dib qaadashada hal mar iyo soo noqnoqda, taas oo saameyn karta dayactirka iyo horumarinta shaqada garashada. Astaxanthin wuxuu kor u qaadaa dib u soo nooleynta unugyada neerfaha wuxuuna kordhiyaa muujinta hidda-wadaha ee borotiinka aashitada glial fibrillary (GFAP), borotiinka la xiriira microtubule 2 (MAP-2), factor neurotrophic ee maskaxda laga helo (BDNF), iyo borotiinka la xiriira koritaanka 43 (GAP-43), borotiinnada lagu lug leeyahay soo kabashada maskaxda.
Kaabsulyada Astaxanthin ee Justgood Health, oo ay weheliyaan Cytisine iyo Astaxanthin oo ka yimid kaymaha Cas ee Algae, ayaa isku dara si loo horumariyo shaqada garashada ee maskaxda.
2) Ilaalinta Indhaha
Astaxanthin wuxuu leeyahay firfircooni ka hortagta oksaydhka kaas oo dhexdhexaadiya molecules-ka xagjirka ah ee aan oksijiinta lahayn isla markaana ilaaliya indhaha. Astaxanthin wuxuu si isku mid ah ula shaqeeyaa carotenoids-ka kale ee taageera caafimaadka indhaha, gaar ahaan lutein iyo zeaxanthin. Intaa waxaa dheer, astaxanthin wuxuu kordhiyaa heerka socodka dhiigga ee isha, taasoo u oggolaanaysa dhiiggu inuu dib u oksijiiyo u sameeyo retina iyo unugyada indhaha. Daraasaduhu waxay muujiyeen in astaxanthin, oo ay weheliso carotenoids-ka kale, ay indhaha ka ilaaliso waxyeelada ka timaadda iftiinka qorraxda. Intaa waxaa dheer, astaxanthin wuxuu ka caawiyaa yareynta raaxo la'aanta indhaha iyo daalka aragga.
Jeljilada Ilaalinta Iftiinka Buluugga ah ee Justgood Health, Waxyaabaha Muhiimka ah: lutein, zeaxanthin, astaxanthin.
3) Daryeelka Maqaarka
Cadaadiska oksaydhku waa kiciyaha muhiimka ah ee gabowga maqaarka aadanaha iyo dhaawaca maqaarka. Habka gabowga gudaha (waqtiga) iyo dibadda (iftiinka) labadaba waa soo saarista ROS, gudaha iyada oo loo marayo dheef-shiid kiimikaad oksaydh, iyo dibadda iyada oo loo marayo soo-gaadhista fallaaraha ultraviolet-ka qorraxda (UV). Dhacdooyinka oksaydhku ku dhaco gabowga maqaarka waxaa ka mid ah dhaawaca DNA-da, jawaabaha bararka, dhimista antioxidants-ka, iyo soo saarista matrix metalloproteinases (MMPs) oo burburiya kolajka iyo elastin ee maqaarka.
Astaxanthin wuxuu si wax ku ool ah u joojin karaa dhaawaca oksaydhka ee xagjirka ah ee xorta ah iyo kicinta MMP-1 ee maqaarka ka dib soo-gaadhista UV. Daraasaduhu waxay muujiyeen in astaxanthin ka yimaada Erythrocystis rainbowensis uu kordhin karo maaddada kolajka isagoo joojinaya muujinta MMP-1 iyo MMP-3 ee fibroblasts-ka maqaarka aadanaha. Intaa waxaa dheer, astaxanthin wuxuu yareeyay dhaawaca DNA-da ee uu keeno UV wuxuuna kordhiyay dayactirka DNA-da ee unugyada la kulma shucaaca UV.
Justgood Health hadda waxay waddaa daraasado dhowr ah, oo ay ku jiraan jiirarka aan timaha lahayn iyo tijaabooyinka aadanaha, kuwaas oo dhammaantood muujiyay in astaxanthin uu yareeyo waxyeelada UV ee lakabyada qoto dheer ee maqaarka, taasoo keenta muuqaalka calaamadaha gabowga maqaarka, sida qallayl, maqaarka oo libdha iyo laalaab.
4) Nafaqada ciyaaraha
Astaxanthin wuxuu dedejin karaa dayactirka jimicsiga kadib. Marka dadku jimicsadaan ama ay jimicsadaan, jirku wuxuu soo saaraa xaddi badan oo ROS ah, kaas oo, haddii aan laga saarin waqtigeeda, dhaawici kara muruqyada oo saameyn kara soo kabashada jirka, halka shaqada xooggan ee antioxidant-ka astaxanthin ay ka saari karto ROS waqtigeeda isla markaana si dhakhso ah u hagaajin karto muruqyada dhaawacan.
Justgood Health waxay soo bandhigaysaa Astaxanthin Complex cusub, oo ah isku-darka badan ee magnesium glycerophosphate, fiitamiin B6 (pyridoxine), iyo astaxanthin kaas oo yareeya xanuunka murqaha iyo daalka ka dib jimicsiga. Qaacidadu waxay ku salaysan tahay Justgood Health's Whole Algae Complex, kaas oo bixiya astaxanthin dabiici ah oo aan kaliya ka ilaalin muruqyada waxyeelada oksaydhka, laakiin sidoo kale kor u qaada waxqabadka murqaha iyo hagaajinta waxqabadka ciyaaraha.
5) Caafimaadka Wadnaha iyo Xididdada
Walwalka oksaydhka iyo bararka ayaa astaan u ah cudurrada wadnaha iyo xididdada dhiigga ee atherosclerotic. Firfircoonida antioxidant-ka ee heer sare ah ee astaxanthin waxay ka hortagi kartaa oo hagaajin kartaa atherosclerosis.
Justgood Health Triple Strength Natural Astaxanthin Softgels waxay gacan ka geystaan ilaalinta caafimaadka wadnaha iyo xididdada dhiigga iyagoo adeegsanaya astaxanthin dabiici ah oo laga helo algae cas ee qaanso roobaadka, oo maaddooyinka ugu muhiimsan ay ka mid yihiin astaxanthin, saliidda qumbaha bikrada ah ee dabiiciga ah iyo tocopherols dabiici ah.
6) Xakamaynta Difaaca Jirka
Unugyada difaaca jirka aad bay ugu nugul yihiin waxyeelada xagjirka xorta ah. Astaxanthin wuxuu ilaaliyaa difaaca habdhiska difaaca jirka isagoo ka hortagaya waxyeelada xagjirka xorta ah. Daraasad ayaa lagu ogaaday in astaxanthin ee unugyada aadanaha si uu u soo saaro immunoglobulin, kaabista astaxanthin ee jirka aadanaha muddo 8 toddobaad ah, heerarka astaxanthin ee dhiigga ayaa kordhay, unugyada T iyo unugyada B ayaa kordhay, dhaawaca DNA-da ayaa yaraaday, borotiinka C-reactive-ka ayaa si weyn hoos ugu dhacay.
Jeljilada jilicsan ee Astaxanthin, astaxanthin cayriin ah, waxay isticmaalaan iftiinka qorraxda dabiiciga ah, biyaha lagu sifeeyay lava iyo tamarta qorraxda si ay u soo saaraan astaxanthin saafi ah oo caafimaad qaba, kaas oo gacan ka geysan kara kor u qaadista difaaca jirka, ilaalinta aragga iyo caafimaadka kala-goysyada.
7) Yaree Daalka
Daraasad laba-geesood ah oo 4 toddobaad socotay oo aan kala sooc lahayn, indho-la'aan ah, placebo-xakamaysan, oo laba-geesood ah ayaa lagu ogaaday in astaxanthin uu dhiirrigeliyo soo kabashada daalka maskaxda ee uu keeno terminal-ka muuqaalka (VDT), isagoo yareynaya heerarka sare ee phosphatidylcholine hydroperoxide (PCOOH) ee plasma inta lagu jiro dhaqdhaqaaqa maskaxda iyo jirka labadaba. Sababtu waxay noqon kartaa dhaqdhaqaaqa antioxidant-ka iyo habka ka hortagga bararka ee astaxanthin.
8) Ilaalinta beerka
Astaxanthin wuxuu leeyahay saameyn ka hortag ah iyo mid wanaagsan oo ku saabsan dhibaatooyinka caafimaad sida fibrosis-ka beerka, dhaawaca beerka ee ischemia-reperfusion, iyo NAFLD. Astaxanthin wuxuu nidaamin karaa noocyo kala duwan oo dariiqooyin calaamadayn ah, sida yareynta dhaqdhaqaaqa JNK iyo ERK-1 si loo hagaajiyo iska caabbinta insulin-ta beerka, joojinta muujinta PPAR-γ si loo yareeyo isku-darka dufanka beerka, iyo hoos u dhigista muujinta TGF-β1/Smad3 si loo joojiyo dhaqdhaqaaqa HSCs iyo fibrosis-ka beerka.
Xaaladda xeerarka waddan kasta
Shiinaha,astaxanthin Laga soo bilaabo isha algae-ga cas ee qaanso roobaadka waxaa loo isticmaali karaa qayb cunto cusub ah oo ku jirta cuntada guud (marka laga reebo cuntada ilmaha), marka lagu daro, Mareykanka, Kanada iyo Japan ayaa sidoo kale u oggolaanaya in astaxanthin loo isticmaalo cuntada.
Waqtiga boostada: Diseembar-05-2024