Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) waa carotenoid, oo loo kala saaro lutein, laga helo noocyo kala duwan oo nooleyaal iyo xayawaan badeed, asal ahaanna laga soocay lobsters by Kuhn iyo Sorensen Waa midab dufan milmay oo u muuqda liimi ilaa casaan qoto dheer oo midab leh oo aan lahayn fiitamiin A firfircoonida jidhka bini'aadamka.
Ilaha dabiiciga ah ee astaxanthin waxaa ka mid ah algae, khamiir, salmon, trout, krill iyo crayfish. Ganacsiga astaxanthin waxaa inta badan laga soo qaatay khamiirka Fife, algae cas iyo kiimikaad isku dhafan. Mid ka mid ah ilaha ugu wanaagsan ee astaxanthin dabiiciga ah waa chlorella casaanka ah ee roobka leh, oo leh maaddo astaxanthin ah oo ku saabsan 3.8% (miisaanka qallalan), iyo salmon duurjoogta ah ayaa sidoo kale ah ilo wanaagsan oo astaxanthin ah. Wax soo saarka synthetic ayaa weli ah isha ugu weyn ee astaxanthin sababtoo ah qiimaha sare ee beerashada ballaaran ee Rhodococcus rainieri. Dhaqdhaqaaqa bayoolojiga ee astaxanthin synthetically soo saaray waa 50% kaliya ee astaxanthin dabiiciga ah.
Astaxanthin waxay u jirtaa sida stereoisomers, isomers joomatari, foomamka bilaashka ah iyo esterified, oo leh stereoisomers (3S,3'S) iyo (3R,3'R) oo ah kuwa ugu badan ee dabiiciga ah. Rhodococcus rainieri waxay soo saartaa (3S,3'S) -isomer iyo khamiirka Fife waxay soo saartaa (3R,3'R) -isomer.
Astaxanthin, kulaylka waqtiga
Astaxanthin waa walaxda xiddiga ee cuntooyinka functional ee Japan. Tirakoobka FTA ee ku saabsan ku dhawaaqida cuntada functional ee Japan ee 2022 lagu ogaaday in astaxanthin lagu daray No. 7 ka mid ah 10ka maaddooyinka ugu sarreeya marka la eego inta jeer ee isticmaalka, iyo inta badan loo isticmaalo in beeraha caafimaadka daryeelka maqaarka, daryeelka indhaha, dhimista daalka, iyo hagaajinta shaqada garashada.
Abaalmarinnada 2022 iyo 2023 ee Abaalmarinta Walxaha Nafaqeynta Aasiya, Walxaha astaxanthin ee dabiiciga ah ee Justgood Health waxaa loo aqoonsaday inay tahay walaxda ugu wanaagsan sanadka laba sano oo isku xigta, walaxda ugu fiican ee shaqada garashada sanadka 2022, iyo qaybta ugu wanaagsan ee wadada quruxda afka 2023. Intaa waxaa dheer, maaddada ayaa lagu daray liiska Aasiya Abaalmarinnada Walxaha Nafaqada - Jidka gabowga caafimaadka qaba ee 2024.
Sanadihii la soo dhaafay, cilmi baarista tacliinta ee astaxanthin ayaa sidoo kale bilaabay in ay kululeyso. Sida laga soo xigtay xogta PubMed, horaantii 1948, waxaa jiray daraasado ku saabsan astaxanthin, laakiin dareenka ayaa hoos u dhacay, laga bilaabo 2011, akadeemiyadda ayaa bilaabay inay diiradda saarto astaxanthin, iyada oo in ka badan 100 daabacaad sannadkii, iyo in ka badan 200 ee 2017, in ka badan in ka badan 300 sanadka 2020, iyo in ka badan 400 sanadka 2021.
Isha sawirka:PubMed
Dhanka suuqa, marka loo eego aragtida suuqa mustaqbalka, cabbirka suuqa astaxanthin ee caalamiga ah waxaa lagu qiyaasaa inuu ahaado USD 273.2 milyan sanadka 2024 waxaana la saadaalinayaa inuu gaaro USD 665.0 milyan marka la gaaro 2034, marka loo eego CAGR oo ah 9.3% inta lagu jiro xilliga saadaasha (2024-2034) ).
Awoodda antioxidant sare
Qaab dhismeedka gaarka ah ee Astaxanthin ayaa siinaya awood antioxidant heer sare ah. Astaxanthin waxa uu ka kooban yahay bonds double conjugated, hydroxyl iyo ketone kooxaha, oo waa lipophilic iyo hydrophilic labadaba. Isku-xidhka labanlaaban ee isku-xidhan ee xarunta xarunta waxay siisaa electrons waxayna la falgashaa xag-jirrada xorta ah si ay ugu beddelaan badeecooyin xasilloon oo ay joojiyaan fal-celinta silsiladda xagjirka ah ee xorta ah ee noolaha kala duwan. Dhaqdhaqaaqeeda bayooloji ayaa ka sarreeya kuwa kale ee antioxidants sababtoo ah awoodda ay u leedahay inay ku xirto xuubka unugyada gudaha gudaha.
Goobta astaxanthin iyo antioxidants kale ee xuubabka unugyada
Astaxanthin waxay qabataa firfircoonida antioxidant ee muhiimka ah ma aha oo kaliya iyada oo si toos ah loo xoqayo xagjirnimada bilaashka ah, laakiin sidoo kale iyada oo loo marayo kicinta nidaamka difaaca unugyada antioxidant-ka iyada oo nidaaminaysa habka nukliyeerka erythroid 2-related factor (Nrf2). Astaxanthin waxay xakameysaa samaynta ROS waxayna xakameysaa muujinta oksijiinta cadaadiska ka jawaab celinta enzymes, sida heme oxygenase-1 (HO-1), taas oo ah calaamad muujinaysa cadaadiska oksaydhka.HO-1 waxaa lagu maamulaa noocyo kala duwan oo qoraal ah oo xasaasi ah arrimo, oo ay ku jiraan Nrf2, kaas oo ku xidhan walxaha ka jawaaba antioxidant-ka ee gobolka dhiirrigeliye ee enzymes-shiid kiimikaad.
Kala duwanaanshaha buuxa ee faa'iidooyinka iyo codsiyada astaxanthin
1) Hagaajinta shaqada garashada
Daraasado badan ayaa xaqiijiyay in astaxanthin laga yaabo inay dib u dhigto ama wanaajiso cilladaha garashada ee la xidhiidha gabowga caadiga ah ama ay hoos u dhigto pathophysiology ee cudurrada neurodegenerative ee kala duwan. Astaxanthin waxay ka gudbi kartaa xannibaadda dhiigga-maskaxda, cilmi-baadhisyaduna waxay muujiyeen in astaxanthin-cuntadu ay ku ururto hippocampus iyo kiliyaha maskaxda ee maskaxda jiirka ka dib qaadashada keli ah iyo soo noqnoqda, taas oo saameyn karta dayactirka iyo hagaajinta shaqada garashada. Astaxanthin waxay kor u qaadaa dib-u-soo-nooleynta unugyada dareemayaasha waxayna kordhisaa muujinta hidda-wadaha ee borotiinka glial fibrillary acidic (GFAP), borotiinka microtubule-laxiriira 2 (MAP-2), factor neurotrophic-maskaxda (BDNF), iyo borotiinka laxiriira korriinka 43 (GAP-43), borotiinno ku lug leh soo kabashada maskaxda.
Justgood Health Astaxanthin Capsules, oo leh Cytisine iyo Astaxanthin oo ka socda Red Algae Rainforest, waxay isu keenaan si ay u horumariyaan shaqada garashada maskaxda.
2) Ilaalinta Indhaha
Astaxanthin waxay leedahay firfircoonida antioxidant ka soo saarta unugyada oksijiinta ee xagjirka ah waxayna siisaa ilaalinta indhaha. Astaxanthin waxay si isku mid ah ula shaqeysaa carotenoids kale ee taageera caafimaadka indhaha, gaar ahaan lutein iyo zeaxanthin. Intaa waxaa dheer, astaxanthin waxay kordhisaa heerka qulqulka dhiigga ee isha, taasoo u oggolaanaysa dhiiggu inuu dib u soo celiyo retina iyo unugyada isha. Daraasaduhu waxay muujiyeen in astaxanthin, oo ay weheliso carotenoids kale, ay ka ilaaliso indhuhu waxyeello ka soo gaarto spectrum qorraxda. Intaa waxaa dheer, astaxanthin waxay kaa caawineysaa yareynta raaxo la'aanta indhaha iyo daalka aragga.
Justgood Health Ilaalinta Iftiinka Buluugga ah ee Softgels, maaddooyinka muhiimka ah: lutein, zeaxanthin, astaxanthin.
3) Daryeelka Maqaarka
Cadaadiska Oxidative waa kicinta muhiimka ah ee gabowga maqaarka bini'aadamka iyo dhaawaca maqaarka. Habka da'da ah ee dabiiciga ah (chronological) iyo extrinsic (iftiinka) labadaba waa soo saarista ROS, gudaha iyada oo loo marayo dheef-shiid kiimikaad, iyo dibadda iyada oo la soo bandhigo fallaadhaha ultraviolet (UV). Dhacdooyinka Oxidative ee gabowga maqaarka waxaa ka mid ah waxyeelada DNA-da, jawaab-celinta caabuqa, dhimista antioxidants, iyo soo saarista matrix metalloproteinases (MMPs) taas oo hoos u dhigta kolajka iyo elastin ee maqaarka.
Astaxanthin waxay si wax ku ool ah u joojin kartaa xagjirnimada lacag-la'aanta ah ee waxyeelada oksaydhka iyo kicinta MMP-1 ee maqaarka ka dib soo-gaadhista UV. Daraasaduhu waxay muujiyeen in astaxanthin ka Erythrocystis rainbownsis ay kordhin karto maadada kolajka iyada oo la joojinayo muujinta MMP-1 iyo MMP-3 ee fibroblasts maqaarka bini'aadamka. Intaa waxaa dheer, astaxanthin waxay yaraysay waxyeelada UV-ku keentay DNA iyo kordhinta hagaajinta DNA ee unugyada soo gaadhay shucaaca UV.
Justgood Health waxa ay hadda waddaa daraasado dhowr ah oo ay ka mid yihiin Jiirka aan timaha lahayn iyo tijaabooyin bani’aadam ah, kuwaas oo dhammaantood caddeeyey in astaxanthin ay hoos u dhigto waxyeellada UV ee lakabyada hoose ee maqaarka, taas oo keenta muuqaalka calaamadaha gabowga maqaarka, sida qallayl, maqaarka oo sii yaraada iyo laalaabkii
4) Nafaqada ciyaaraha
Astaxanthin waxay dedejin kartaa dayactirka jimicsiga kadib. Marka ay dadku jimicsi sameeyaan ama jimicsi sameeyaan, jidhku wuxuu soo saaraa xaddi badan oo ROS ah, taas oo, haddii aan laga saarin wakhtiga, waxay dhaawici kartaa murqaha waxayna saameyneysaa soo kabashada jirka, halka shaqada adag ee astaxanthin ay ka saari karto ROS waqtigeeda isla markaana si dhakhso ah u hagaajin karto muruqyada dhaawacan.
Justgood Health waxay soo bandhigaysaa Astaxanthin Complex-keeda cusub, isku darka badan ee magnesium glycerophosphate, vitamin B6 (pyridoxine), iyo astaxanthin kaas oo yareeya xanuunka murqaha iyo daalka jimicsiga kadib. Nafaqadu waxay ku taal agagaarka Justgood Health's Whole Algae Complex, kaas oo bixiya astaxanthin dabiiciga ah oo aan kaliya ka ilaalinaynin murqaha waxyeelada oksaydhka, laakiin sidoo kale waxay kordhisaa waxqabadka muruqa waxayna hagaajisaa waxqabadka ciyaaraha fudud.
5) Caafimaadka Wadnaha
Cadaadiska Oxidative iyo bararka ayaa tilmaamaya pathophysiology ee cudurada wadnaha atherosclerotic. Dhaqdhaqaaqa ugu fiican ee antioxidant-ka ee astaxanthin ayaa ka hortagi kara oo wanaajin kara atherosclerosis.
Justgood Health Triple Strength Dabiiciga Astaxanthin Softgels waxay caawiyaan ilaalinta caafimaadka wadnaha iyadoo la isticmaalayo astaxanthin dabiiciga ah oo ka soo jeeda algae cas qaan qaansoroobaad, maaddooyinka ugu muhiimsan ee ay ku jiraan astaxanthin, saliid qumbaha bikrad organic iyo tocopherols dabiiciga ah.
6) Nidaaminta difaaca jirka
Unugyada difaaca jirka aad ayey ugu nugul yihiin waxyeelada xagjirka xorta ah. Astaxanthin waxa ay ilaalisaa difaaca hab-dhiska difaaca iyada oo ka hortagaysa waxyeelada xagjirnimada xorta ah. Daraasad ayaa lagu ogaaday in astaxanthin ee unugyada bini'aadamka si ay u soo saaraan immunoglobulins, jidhka bini'aadamka astaxanthin supplementation for 8 toddobaad, heerarka astaxanthin ee dhiigga kor u kacay, T unugyada iyo B unugyada kor u kacay, dhaawaca DNA waa la dhimay, C-reactive protein si weyn hoos ugu dhacay.
Astaxanthin softgels, astaxanthin cayriin, waxay isticmaalaan iftiinka qorraxda dabiiciga ah, biyaha lafa-miiray iyo tamarta qorraxda si ay u soo saaraan astaxanthin saafi ah oo caafimaad leh, taas oo gacan ka geysan karta kor u qaadida difaaca, ilaalinta aragga iyo caafimaadka wadajirka.
7) Daalka ka saar
4-usbuuc oo randomized ah, laba-indho la'aan, placebo-koontarool, daraasad laba-geesood ah ayaa lagu ogaaday in astaxanthin uu kor u qaaday ka soo kabashada muuqaalka muuqaalka (VDT) ee daalka maskaxda, hoos u dhigista heerarka sare ee phosphatidylcholine hydroperoxide (PCOOH) inta lagu jiro labadaba maskaxda iyo jirka labadaba. hawlqabad. Sababtu waxay noqon kartaa dhaqdhaqaaqa antioxidant iyo habka anti-bararka ee astaxanthin.
8) Ilaalinta beerka
Astaxanthin waxay leedahay saameyn ka hortag ah oo hagaajin ah dhibaatooyinka caafimaadka sida beerka fibrosis, dhaawaca ischemia-reperfusion beerka, iyo NAFLD. Astaxanthin waxay nidaamin kartaa noocyo kala duwan oo dariiqooyin calaamad ah, sida hoos u dhigista dhaqdhaqaaqa JNK iyo ERK-1 si loo hagaajiyo caabbinta insulin-cagaarshow, joojinta muujinta PPAR-γ si loo yareeyo isku-dhafka dufanka beerka, iyo hoos u dhigista TGF-β1 / Smad3 muujinta si loo xakameeyo dhaqdhaqaaqa HSCs iyo beerka fibrosis.
Heerka xeerarka ee waddan kasta
Dalka Shiinaha, astaxanthin laga soo bilaabo isha algae cas qaansoroobaad waxaa loo isticmaali karaa sida qayb cusub oo cunto ah cuntada guud (marka laga reebo cuntada ilmaha), marka lagu daro, Maraykanka, Kanada iyo Japan ayaa sidoo kale u ogolaanaya astaxanthin in loo isticmaalo cuntada.
Waqtiga boostada: Dec-05-2024